User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Glomerular filtration rate: assessment with dynamic contrast-enhanced MRI and a cortical-compartment model in the rabbit kidney.

Primary tabs

Annet, Laurence [UCL] Hermoye, Laurent [UCL] Peeters, Frank [UCL] Jamar, François [UCL] Dehoux, Jean-Paul [UCL] Van Beers, Bernard [UCL]

PURPOSE: To describe the use of MRI and a cortical-compartment model to measure the glomerular filtration rate (GFR), and compare the results with those obtained with the Patlak-Rutland model. MATERIALS AND METHODS: Dynamic MRI of rabbit kidneys was performed during and after injection of gadoterate dimeglumine. The enhancement curves in the aorta and the kidney were analyzed with the cortical-compartment and Patlak-Rutland models to assess the GFR. RESULTS: A substantial correlation was observed between the GFR measured with MRI using the cortical-compartment model and the plasma clearance of 51Cr-EDTA (r=0.821, P=0.004). No significant correlation was observed between the 51Cr-EDTA clearance (r=0.628, P=0.052) and the GFR obtained with the Patlak-Rutland model in regions of interest (ROIs) encompassing the renal cortex and medulla. A Bland and Altman analysis showed that GFR(cortical) (compartment) agreed better with the 51Cr-EDTA clearance compared to GFR(Patlak) when ROIs were limited to the cortex. However, the GFR values obtained by MRI were lower than the plasma clearance of 51Cr-EDTA. CONCLUSION: MRI with a cortical-compartment model provides more accurate assessments of glomerular filtration than the Patlak-Rutland model.

Document type Article de périodique (Journal article) – Article de recherche – Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Validation Studies
Access type Accès restreint
Publication date 2004
Language Anglais
Journal information "Journal of magnetic resonance imaging : JMRI" - Vol. 20, no. 5, p. 843-9 (2004)
Peer reviewed yes
issn 1053-1807
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - MD/RAIM - Département de radiologie et d'imagerie médicale
UCL - (SLuc) Service de radiologie
MESH Subject Animals ; Contrast Media - administration & dosage ; Glomerular Filtration Rate - physiology ; Hypovolemia - physiopathology ; Image Enhancement - methods ; Image Processing, Computer-Assisted - methods ; Kidney - anatomy & histology - blood supply - physiology ; Magnetic Resonance Imaging - methods ; Male ; Meglumine - administration & dosage ; Models, Animal ; Organometallic Compounds - administration & dosage ; Rabbits ; Reproducibility of Results ; Time Factors
Keywords Magnetic resonance imaging ; Kidney ; Glomerular filtration rate ; Contrast media ; Mathematical model
Links
  1. Huang, Radiol Clin North Am, 41, 1001 (2003)
  2. Bauer John H., Brooks Charles S., Burch Rebecca N., Clinical Appraisal of Creatinine Clearance as a Measurement of Glomerular Filtration Rate, 10.1016/s0272-6386(82)80091-7
  3. Rahn, J Hypertens, 17, 309 (1999)
  4. Brandstrom, Nephrol Dial Transplant, 13, 1176 (1998)
  5. Rutland, Nucl Med Commun, 6, 11 (1985)
  6. Dawson, Invest Radiol, 28, s79 (1993)
  7. Blomley, Br J Radiol, 69, 989 (1996)
  8. Miles K A, Leggett D A, Bennett G A, CT derived Patlak images of the human kidney., 10.1259/bjr.72.854.10365065
  9. Tsushima, J Urol, 165, 382 (2001)
  10. Hackstein Nils, Bauer Julia, Hauck Ekkehard W., Ludwig Martin, Krämer Hans-Joachim, Rau Wigbert Stefan, Measuring Single-Kidney Glomerular Filtration Rate on Single-Detector Helical CT Using a Two-Point Patlak Plot Technique in Patients with Increased Interstitial Space, 10.2214/ajr.181.1.1810147
  11. Niendorf E R, Grist T M, Lee F T, Brazy P C, Santyr G E, Rapid in vivo measurement of single-kidney extraction fraction and glomerular filtration rate with MR imaging., 10.1148/radiology.206.3.9494503
  12. Coulam, Radiology, 223, 76 (2002)
  13. Lee, Radiology, 227, 289 (2003)
  14. Baumann, Magn Reson Imaging, 18, 587 (2000)
  15. Laurent, Magn Reson Med, 47, 127 (2002)
  16. Hackstein, J Magn Reson Imaging, 18, 714 (2003)
  17. Teh Hui Seong, Ang Ee Sin, Wong Weng Cheong, Tan Say Beng, Tan Andrew Gee Seng, Chng Soke Miang, Lin Michael Beng Kiang, Goh Jeffery Seow Kuang, MR Renography Using a Dynamic Gradient-Echo Sequence and Low-Dose Gadopentetate Dimeglumine as an Alternative to Radionuclide Renography, 10.2214/ajr.181.2.1810441
  18. Piepsz, Nucl Med Commun, 17, 817 (1996)
  19. Quantitative measurement of blood perfusion, GFR and arterial vascular fraction in the kidney cortex. In: Proceedings of the 9th Annual Meeting of ISMRM, Glasgow, Scotland, 2001. p 367.
  20. Pinnick, Am J Physiol, 250, f86 (1986)
  21. Lipman, Lab Anim Sci, 40, 395 (1990)
  22. Chantler, Clin Sci, 37, 169 (1969)
  23. Peters, Eur J Nucl Med, 28, 320 (2001)
  24. Materne, Magn Reson Med, 47, 135 (2002)
  25. Peeters, Magn Reson Med, 51, 710 (2004)
  26. Aumann, Magn Reson Med, 49, 276 (2003)
  27. Van Beers, Magn Reson Med, 49, 692 (2003)
  28. Daldrup H, Shames D M, Wendland M, Okuhata Y, Link T M, Rosenau W, Lu Y, Brasch R C, Correlation of dynamic contrast-enhanced MR imaging with histologic tumor grade: comparison of macromolecular and small-molecular contrast media., 10.2214/ajr.171.4.9762973
  29. Frennby, Acad Radiol, 3, 651 (1996)
  30. Hegedüs V., Faarup P., Cortical Volume of the Normal Human Kidney : Correlated Angiographic and Morphologic Investigations, 10.1177/028418517201200409
  31. Dunnill, J Pathol, 110, 113 (1973)
  32. Bland, Stat Methods Med Reson, 8, 135 (1999)
  33. Biostatistics. Hamilton: B.C. Decker; 1998. 324 p.
  34. Transit time, clearance, distribution volume and extraction fraction. In: editors. Physiological measurements with radionuclides in clinical practice. New York: Oxford University Press; 1998. p 28-44.
  35. Wolf, Am J Kidney Dis, 33, 804 (1999)
  36. Hillman, Invest Radiol, 17, 41 (1982)
  37. Landis, Magn Reson Med, 42, 467 (1999)
  38. Sanford, Lab Anim Sci, 30, 519 (1980)
  39. Hermoye, Magn Reson Med, 51, 1017 (2004)
Bibliographic reference Annet, Laurence ; Hermoye, Laurent ; Peeters, Frank ; Jamar, François ; Dehoux, Jean-Paul ; et. al. Glomerular filtration rate: assessment with dynamic contrast-enhanced MRI and a cortical-compartment model in the rabbit kidney.. In: Journal of magnetic resonance imaging : JMRI, Vol. 20, no. 5, p. 843-9 (2004)
Permanent URL http://hdl.handle.net/2078.1/10006