Modelling a gene regulatory network involved in cholangiocarcinoma

Cholangiocarcinoma is an aggressive, uncommon cancer. Furthermore, factors causing cholangiocarcinoma are unknown and lowly understood. All of this leads to late diagnosis and weak survival chances of 5% within 5 years after diagnosis. In need to better understand the mechanisms of tumorigenesis, Mickaël Di-Luoffo within the de Duve institute develop a mice model that highlighted the structure of a gene network involved in cholangiocarcinoma growth. On basis of this previous work, this master thesis suggests a modelling sequence for the construction of a quantitative mathematical model imitating the behavior of this gene network.