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Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide

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Cerf, Emilie [Center for Structural Biology and Bioinformatics, Laboratory for Structure and Function of Biological Membranes, Faculte des Sciences, Universite Libre de Bruxelles] Sarroukh, Rabia [Faculte des Sciences, Universite Libre de Bruxelles] Tamamizu-Kato, Shiori [Martin Luther King Jr. Way, Oakland, CA 94609, U.S.A.] Breydo, Leonid [University of California at Irvine, 3438 McGaugh Hall, Irvine, CA 92697, U.S.A] Derclaye, Sylvie [UCL] Dufrêne, Yves [UCL] Raussens, Vincent [Faculte des Sciences, Universite Libre de Bruxelles]

AD (Alzheimer's disease) is linked to A beta (amyloid beta-peptide) misfolding. Studies demonstrate that the level Of Soluble A beta oligomeric forms correlates better with the progression of the disease than the level of fibrillar forms. Conformation-dependent antibodies have been developed to detect either A beta oligomers or fibrils, suggesting that structural differences between these forms of At exist. Using conditions which yield well-defined A beta (1-42) oligomers or fibrils, We studied the secondary structure of these species by ATR (attenuated total reflection)-FTIR (Fourier-transform infrared) spectroscopy. Whereas fibrillar A beta was organized in a parallel beta-sheet conformation, oligomeric A beta displayed distinct spectral features, which were attributed to an antiparallel beta-sheet structure. We also noted striking similarities between A beta oligomers spectra and those of bacterial outer membrane porins. We discuss our results in terms of a possible organization of the antiparallel beta-sheets in A beta oligomers, which may be related to reported effects of these highly toxic species in the amyloid pathogenesis associated with AD.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2009
Language Anglais
Journal information "Biochemical Journal" - Vol. 421, p. 415-423 (2009)
Peer reviewed yes
Publisher Portland Press Ltd (London)
issn 0264-6021
e-issn 1470-8728
Publication status Publié
Affiliation UCL - AGRO/CABI - Département de chimie appliquée et des bio-industries
Keywords Alzheimer's disease ; amyloid beta-peptide ; antiparallel beta-sheet ; infrared spectroscopy ; oligomeric A beta ; OmpF
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Bibliographic reference Cerf, Emilie ; Sarroukh, Rabia ; Tamamizu-Kato, Shiori ; Breydo, Leonid ; Derclaye, Sylvie ; et. al. Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide. In: Biochemical Journal, Vol. 421, p. 415-423 (2009)
Permanent URL http://hdl.handle.net/2078.1/35432